Abstract: A series of 2-(3-(4-Chlorobenzamido) -2-(aryl)4 oxo -thiazolidines were prepared by treating substituted 4 chlorobenzo hydrazide with reaction of thiomalic acid.
Structures of the newly synthesized compounds were assigned on the basis of elemental analysis, IR, 1H NMR.Keywords: Thiazolidinone derivatives, Schiff base, different aldehyde,Thiomalic acid.Introduction: Heterocyclic compounds are an important class of compounds, making up more than half of all the known organic compounds. Heterocyclic compounds are very widely distributed in nature and are particularly important because of the wide variety of pharmalogical activities.4-Thiazolidinone derivatives play an important role in many biological processes and synthetic drugs. They also play an important role in variety of pharmacological activities.
4-Thiazolidinones is the core of many pharmacological agents.4-Thiazolidinones moiety has a broad spectrum of biological activities such as, antiviral 1, anticancer 2, 3, anti-tubercular 4, antimicrobial 5-17 etc.From above data and reasoning we have directed our work to synthesized a new derivatives consisting of 4-thiazolidinones.